RhoH is important for positive thymocyte selection and T-cell receptor signaling.

  title={RhoH is important for positive thymocyte selection and T-cell receptor signaling.},
  author={Tatjana Dorn and Ursula Kuhn and Gerd Bungartz and Sebastian Berthold Stiller and Martina Bauer and J. Ellwart and Thorsten Peters and Karin Scharffetter-Kochanek and Monika Semmrich and Melanie Laschinger and Bernhard Holzmann and Wolfgang E. F. Klinkert and P Straten and Tania T. K\ollgaard and Michael Sixt and Cord Brakebusch},
  volume={109 6},
RhoH is a small GTPase expressed only in the hematopoietic system. With the use of mice with targeted disruption of the RhoH gene, we demonstrated that RhoH is crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Furthermore, the differentiation and expansion of DN3 and DN4 thymocytes in vitro were severely impaired. These defects corresponded to defective TCR signaling. Although RhoH is not required for TCR-induced activation of ZAP70 and ZAP70-mediated… CONTINUE READING


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