RhoG is required for both FcγR- and CR3-mediated phagocytosis.

  title={RhoG is required for both FcγR- and CR3-mediated phagocytosis.},
  author={George Tzircotis and Vania M. M. Braga and Emmanuelle Caron},
  journal={Journal of cell science},
  volume={124 Pt 17},
Phagocytosis is a highly ordered process orchestrated by signalling through Rho GTPases to locally organise the actin cytoskeleton and drive particle uptake. Specific Rho family members that regulate phagocytosis are not known, as the majority of studies have relied on the use of dominant-negative mutants and/or toxins, which can inactivate multiple Rho GTPases. To identify the relevant GTPases for phagocytosis through the Fcγ receptor (FcγR) and complement receptor 3 (CR3), we depleted 20 Rho… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations

Regulation of phagocytosis by Rho GTPases.

Small GTPases • 2015
View 10 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 31 references

Molecular mechanisms of phagocytic uptake in mammalian cells

Cellular and Molecular Life Sciences • 2008
View 4 Excerpts
Highly Influenced

Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis.

Molecular biology of the cell • 2004
View 9 Excerpts
Highly Influenced

Spatiotemporal activation of Rac1 for engulfment of apoptotic cells.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…