RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo

@article{Katoh2003RhoGAR,
  title={RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo},
  author={Hironori Katoh and Manabu Negishi},
  journal={Nature},
  year={2003},
  volume={424},
  pages={461-464}
}

• Hironori Katoh, Manabu Negishi
• Published 2003 in Nature
• DOI:10.1038/nature01817

The small GTPase Rac has a central role in regulating the actin cytoskeleton during cell migration and axon guidance. Elmo has been identified as an upstream regulator of Rac1 that binds to and functionally cooperates with Dock180 (refs 2–4). Dock180 does not contain a conventional catalytic domain for guanine nucleotide exchange on Rac, but possesses a domain that directly binds to and specifically activates Rac1 (refs 5, 6). The small GTPase RhoG mediates several cellular morphological… CONTINUE READING

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