RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-kinase/myosin phosphatase target pathway.

@article{Ma2013RhoEIF,
  title={RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-kinase/myosin phosphatase target pathway.},
  author={W. T. Ma and Carmen Chak-lui Wong and Edmund Kwok-kwan Tung and Chun Ming Wong and Irene Oi-lin Ng},
  journal={Hepatology},
  year={2013},
  volume={57 1},
  pages={152-61}
}
UNLABELLED Deregulation of Rho guanosine triphosphatase (GTPase) pathways plays an important role in tumorigenesis and metastasis of hepatocellular carcinoma (HCC). RhoE/Rnd3 belongs to an atypical subfamily of the RhoGTPase, the Rnd family, as it lacks the intrinsic GTPase activity and remains always in its active GTP-bound form. In this study we investigated the role of RhoE in HCC. We examined the expression of RhoE in primary HCC samples from patients predominantly infected with the… CONTINUE READING
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