RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress

@article{Ongusaha2006RhoEIA,
  title={RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress},
  author={Pat P. Ongusaha and Hyung-Gu Kim and Sarah A Boswell and Anne J Ridley and Channing J Der and Gian Paolo Dotto and Young-Bum Kim and Stuart A. Aaronson and Sam W. Lee},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={2466-2472}
}
The Rho family of GTPases regulates many aspects of cellular behavior through alterations to the actin cytoskeleton . The majority of the Rho family proteins function as molecular switches cycling between the active, GTP-bound and the inactive, GDP-bound conformations . Unlike typical Rho-family proteins, the Rnd subfamily members, including Rnd1, Rnd2, RhoE (also known as Rnd3), and RhoH, are GTPase deficient and are thus expected to be constitutively active . Here, we identify an unexpected… CONTINUE READING

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