RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.

@article{Kazerounian2013RhoBDC,
  title={RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.},
  author={Shiva Kazerounian and Damien Gerald and Minzhou Huang and Yuet Ming Rebecca Chin and Durga Udayakumar and Ningning Zheng and Ryan O'Donnell and Carole A Perruzzi and Lee Elena Mangiante and Jacob Pourat and Thuy Linh Phung and Arturo Bravo-Nuevo and Sharon Shechter and Stephanie A McNamara and James B DuHadaway and Olivier N. Kocher and Lawrence F. Brown and A. C. Toker and George C Prendergast and Laura Benjamin},
  journal={Cancer research},
  year={2013},
  volume={73 1},
  pages={
          50-61
        }
}
Tumors are composed of cancer cells but also a larger number of diverse stromal cells in the tumor microenvironment. Stromal cells provide essential supports to tumor pathophysiology but the distinct characteristics of their signaling networks are not usually considered in developing drugs to target tumors. This oversight potentially confounds proof-of-concept studies and increases drug development risks. Here, we show in established murine and human models of breast cancer how differential… CONTINUE READING
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