RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.

@article{Adnane2002RhoBNR,
  title={RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.},
  author={Jalila Adnane and Edward R. Seijo and Zhi Chen and Francisco A. Bizouarn and Martha Elizabeth Salazar Leal and Said M Sebti and Teresita Mu{\~n}oz-Antonia},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 10},
  pages={
          8500-7
        }
}
The transforming growth factor-beta (TGF-beta) type I (T beta R-I) and type II (T beta R-II) receptors are responsible for transducing TGF-beta signals. We have previously shown that inhibition of farnesyltransferase activity results in an increase in T beta R-II expression, leading to enhanced TGF-beta binding, signaling, and inhibition of tumor cell growth, suggesting that a farnesylated protein(s) exerts a repressive effect on T beta R-II expression. Likely candidates are farnesylated… CONTINUE READING
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