RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity.

@article{Hu1999RhoASP,
  title={RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity.},
  author={Weimin K Hu and Clifford J. Bellone and Joseph J. Baldassare},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 6},
  pages={3396-401}
}
RhoA has been identified as an important regulator of cell proliferation. We recently showed that the Ras/RhoA pathway regulates the degradation of p27(Kip) and the progression of Chinese hamster embryo fibroblasts (IIC9 cells) through G1 into S phase (Weber, J. D., Hu, W., Jefcoat, S. C., Raben, D. M., and Baldassare, J. J. (1997) J. Biol. Chem. 272, 32966-32971). In this report, we have demonstrated that, in IIC9 cells, RhoA regulates cyclin E/CDK2 activity, which is required for p27(Kip… CONTINUE READING