RhoA signaling via serum response factor plays an obligatory role in myogenic differentiation.

@article{Wei1998RhoASV,
  title={RhoA signaling via serum response factor plays an obligatory role in myogenic differentiation.},
  author={Lei Wei and Wenyun Zhou and Jeffrey D Croissant and F E Johansen and Ron Prywes and Ashok Balasubramanyam and Robert J. Schwartz},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 46},
  pages={30287-94}
}
Serum response factor (SRF) plays a central role during myogenesis, being required for the expression of striated alpha-actin genes. As shown here, the small GTPase RhoA-dependent activation of SRF results in the expression of muscle-specific genes, thereby promoting myogenic differentiation in myoblast cell lines. Co-expression of activated V14-RhoA and SRF results in an approximately 10-fold activation of the skeletal alpha-actin promoter in replicating myoblasts, while SRFpm1, a dominant… CONTINUE READING
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