RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter.

@article{Patel2007RhoAPI,
  title={RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter.},
  author={Chirag A Patel and Satish Rattan},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={321 2},
  pages={501-8}
}
RhoA prenylation is a critical step for the translocation of RhoA to the membrane and its activation in response to agonist-induced sustained contraction of the smooth muscle. However, the effect and role of RhoA prenylation in the spontaneously tonic smooth muscle, such as internal anal sphincter (IAS), is not known. Present studies determined RhoA prenylation and its association with the basal tone in the IAS before and after the RhoA prenylation inhibitor, geranylgeranyl transferase… CONTINUE READING