RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction.


OBJECTIVE Notch signaling has a critical role in vascular development and morphogenesis. Activation of Notch in endothelial cells led to a senescence-like phenotype with loss of barrier function. Our objective was to understand the molecular pathways mediating this phenotype. METHODS AND RESULTS Human primary endothelial cells increase expression of Notch… (More)
DOI: 10.1161/ATVBAHA.110.221945