RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model.

@article{Gwak2017RhoAKB,
  title={RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model.},
  author={So-Jung Gwak and Christian Macks and Da Un Jeong and Mark Kindy and Michael J. Lynn and Ken Webb and Jeoung Soo Lee},
  journal={Biomaterials},
  year={2017},
  volume={121},
  pages={155-166}
}
Spinal cord injury (SCI) results in permanent loss of motor and sensory function due to developmentally-related and injured-induced changes in the extrinsic microenvironment and intrinsic neuronal biochemistry that limit plasticity and axonal regeneration. Our long term goal is to develop cationic, amphiphilic copolymers (poly (lactide-co-glycolide)-g-polyethylenimine, PgP) for combinatorial delivery of therapeutic nucleic acids (TNAs) and drugs targeting these different barriers. In this study… CONTINUE READING