RhoA is required for monocyte tail retraction during transendothelial migration

@article{Worthylake2001RhoAIR,
  title={RhoA is required for monocyte tail retraction during transendothelial migration},
  author={Rebecca A. Worthylake and Sean Lemoine and Joanna M. Watson and Keith Burridge},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={154},
  pages={147 - 160}
}
Transendothelial migration of monocytes is the process by which monocytes leave the circulatory system and extravasate through the endothelial lining of the blood vessel wall and enter the underlying tissue. Transmigration requires coordination of alterations in cell shape and adhesive properties that are mediated by cytoskeletal dynamics. We have analyzed the function of RhoA in the cytoskeletal reorganizations that occur during transmigration. By loading monocytes with C3, an inhibitor of… CONTINUE READING