RhoA induces expression of inflammatory cytokine in adipocytes.

  title={RhoA induces expression of inflammatory cytokine in adipocytes.},
  author={Yuki Nakayama and Ryutaro Komuro and Akiko Yamamoto and Yugo Miyata and Masaki Tanaka and Morihiro Matsuda and Atsunori Fukuhara and Iichiro Shimomura},
  journal={Biochemical and biophysical research communications},
  volume={379 2},
Rho GTPase regulates actin cytoskeleton organization and assembly in many cell types, however, its significance in adipose tissue is not well characterized. Here, we demonstrate high RhoA activity in adipose tissues of C57BL/6J mice. To determine the effect of RhoA activation on 3T3-L1 cells, stable cell lines overexpressing G14VRhoA fused to destabilizing domain of FKBP12 (DD-G14VRhoA-L1) were generated. Treatment of DD-G14VRhoA-L1 cells with Shield1 following their differentiation into… CONTINUE READING