RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.

@article{Solski2002RhoABA,
  title={RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.},
  author={Patricia Solski and Whitney Helms and Patricia J. Keely and Lishan Su and Channing J Der},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={2002},
  volume={13 8},
  pages={363-73}
}
Recent studies showed that specific isoprenoid modification may be critical for RhoB subcellular location and function. Therefore, we determined whether the function of the highly related RhoA protein is also critically dependent on specific isoprenoid modification: (a) in contrast to observations with RhoB or Ras proteins, where farnesylated and geranylgeranylated versions showed differences in subcellular location, both prenylated versions of RhoA showed the same plasma membrane and cytosolic… CONTINUE READING

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