RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling.

@article{Guilluy2009RhoAAR,
  title={RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling.},
  author={Christophe Guilluy and Saadia Eddahibi and C Agard and Christophe Guignabert and Mohamed Izikki and Ly Tu and Laurent Savale and Marc Humbert and {\'E}lie Fadel and Serge Adnot and Gervaise Loirand and Pierre Pacaud},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={179 12},
  pages={1151-8}
}
RATIONALE The complex and multifactorial pathogenesis of pulmonary hypertension (PH) involves constriction, remodeling, and in situ thrombosis of pulmonary vessels. Both serotonin (5-HT) and Rho kinase signaling may contribute to these alterations. OBJECTIVES To investigate possible links between the 5-HT transporter (5-HTT) and RhoA/Rho kinase pathways, as well as their involvement in the progression of human and experimental PH. METHODS Biochemical and functional analyses of lungs… CONTINUE READING