RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific.

@article{Bailly2004RhoAAB,
  title={RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific.},
  author={Karine Bailly and Anne J Ridley and Susan M. Hall and Sheila. G. Haworth},
  journal={Circulation research},
  year={2004},
  volume={94 10},
  pages={1383-91}
}
Hypoxia induces vasoconstriction of pulmonary arteries through contraction of smooth muscle cells (SMCs). The GTPase RhoA regulates smooth muscle contractility and actin cytoskeletal remodeling through the Rho-associated kinase (ROCK). We previously found that the postnatal fall in pulmonary vascular resistance was associated with actin cytoskeletal remodeling in porcine pulmonary arterial SMCs (PASMCs) in vivo. Here, we investigated the effects of acute and chronic hypoxia on the morphology… CONTINUE READING
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