RhoA activation and nuclearization marks loss of chondrocyte phenotype in crosstalk with Wnt pathway.

@article{ztrk2017RhoAAA,
  title={RhoA activation and nuclearization marks loss of chondrocyte phenotype in crosstalk with Wnt pathway.},
  author={Ece {\"O}zt{\"u}rk and Evelin Despot-Slade and Michael Pichler and Marcy Zenobi-Wong},
  journal={Experimental cell research},
  year={2017},
  volume={360 2},
  pages={113-124}
}
De-differentiation comprises a major drawback for the use of autologous chondrocytes in cartilage repair. Here, we investigate the role of RhoA and canonical Wnt signaling in chondrocyte phenotype. Chondrocyte de-differentiation is accompanied by an upregulation and nuclear localization of RhoA. Effectors of canonical Wnt signaling including β-catenin and… CONTINUE READING