RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration.

  title={RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration.},
  author={Matthieu Rousseau and M D Gaugler and Audrey Rodallec and St{\'e}phanie Bonnaud and François Paris and Isabelle Corre},
  journal={Biochemical and biophysical research communications},
  volume={414 4},
Endothelial cells of the microvasculature are major target of ionizing radiation, responsible of the radiation-induced vascular early dysfunctions. Molecular signaling pathways involved in endothelial responses to ionizing radiation, despite being increasingly investigated, still need precise characterization. Small GTPase RhoA and its effector ROCK are crucial signaling molecules involved in many endothelial cellular functions. Recent studies identified implication of RhoA/ROCK in radiation… CONTINUE READING


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