RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes.

@article{Derangeon2008RhoAGA,
  title={RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes.},
  author={Micka{\"e}l Derangeon and Nicolas Bourmeyster and Isabelle Plaisance and Caroline Pinet-Charvet and Qian Chen and Fabien Duthe and Michel Robert Popoff and Denis Sarrouilhe and Jean-Claude Herv{\'e}},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 45},
  pages={30754-65}
}
Gap junctions are clusters of transmembrane channels allowing a passive diffusion of ions and small molecules between adjacent cells. Connexin43, the main channel-forming protein expressed in ventricular myocytes, can associate with zonula occludens-1, a scaffolding protein linked to the actin cytoskeleton and to signal transduction molecules. The possible… CONTINUE READING