RhoA–ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells

@article{OrdezMorn2008RhoAROCKAP,
  title={RhoA–ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells},
  author={Paloma Ord{\'o}{\~n}ez-Mor{\'a}n and Mar{\'i}a Jes{\'u}s Larriba and H{\'e}ctor G. P{\'a}lmer and Ruth Ana Valero and Antonio Barb{\'a}chano and Mireia Du{\~n}ach and Antonio Garc{\'i}a de Herreros and Carlos Villalobos and Mar{\'i}a Teresa Berciano and Miguel Lafarga and Alberto Mu{\~n}oz},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={183},
  pages={697 - 710}
}
The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. Additionally, 1,25(OH)(2)D(3) has several nongenomic effects of uncertain relevance. We show that 1,25(OH)(2)D(3) induces a transcription-independent Ca(2+) influx and activation of RhoA-Rho-associated coiled kinase (ROCK). This… CONTINUE READING

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