Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II

@inproceedings{Yashiro2014Rho1RA,
  title={Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II},
  author={Hanako Yashiro and Andrew J. Loza and James B Skeath and Gregory D. Longmore},
  booktitle={Molecular biology of the cell},
  year={2014}
}
Once adherens junctions (AJs) are formed between polarized epithelial cells they must be maintained because AJs are constantly remodeled in dynamic epithelia. AJ maintenance involves endocytosis and subsequent recycling of E-cadherin to a precise location along the basolateral membrane. In the Drosophila pupal eye epithelium, Rho1 GTPase regulates AJ remodeling through Drosophila E-cadherin (DE-cadherin) endocytosis by limiting Cdc42/Par6/aPKC complex activity. We demonstrate that Rho1 also… CONTINUE READING
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