Rho plays an important role in angiotensin II-induced hypertrophic responses in cardiac myocytes

@article{Aikawa2000RhoPA,
  title={Rho plays an important role in angiotensin II-induced hypertrophic responses in cardiac myocytes},
  author={Ryuichi Aikawa and Issei Komuro and Ryozo Nagai and Yoshio Yazaki},
  journal={Molecular and Cellular Biochemistry},
  year={2000},
  volume={212},
  pages={177-182}
}
Angiotensin II (Ang II) evokes a variety of hypertrophic responses such as activation of protein kinases, reprogramming of gene expressions and an increase in protein synthesis in cardiac myocytes. In this study, we examined the role of Rho family small GTP binding proteins (G proteins) in Ang II-induced cardiac hypertrophy. Ang II strongly activated extracellular signal-regulated protein kinases (ERKs) in cardiac myocytes of neonatal rats. Although Ang II-induced activation of ERKs was… CONTINUE READING