Rho plays a key role in TGF-beta1-induced cytoskeletal rearrangement in human retinal pigment epithelium.

@article{Lee2008RhoPA,
  title={Rho plays a key role in TGF-beta1-induced cytoskeletal rearrangement in human retinal pigment epithelium.},
  author={Jungeun Lee and Meekyung Ko and Choun-Ki Joo},
  journal={Journal of cellular physiology},
  year={2008},
  volume={216 2},
  pages={520-6}
}
Proliferative vitroretinopathy (PVR) is caused by retinal pigment epithelial (RPE) cell proliferation and transformation into fibrotic cells that produce extracellular matrix (ECM) components. Transforming growth factor beta1 (TGF-beta1) is known to play an important role in PVR pathogenesis. To determine how TGF-beta1 mediates the pathogenic changes in RPE cells, we characterized the effects of TGF-beta1 on the morphology, ECM accumulation, and stress fiber formation of ARPE-19 cells, a human… CONTINUE READING

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