Rho-kinase mediates TNF-α-induced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells.

@article{Matoba2010RhokinaseMT,
  title={Rho-kinase mediates TNF-α-induced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells.},
  author={Keiichiro Matoba and Daiji Kawanami and Sho Ishizawa and Yasushi Kanazawa and Tamotsu Yokota and Kazunori Utsunomiya},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={402 4},
  pages={725-30}
}
Macrophage accumulation has been implicated in the pathogenesis of inflammatory glomerular disease. Monocyte chemoattractant protein-1 (MCP-1) plays a central role in recruiting monocytes to the glomeruli. Tumor necrosis factor-α (TNF-α) has been shown to induce MCP-1 expression in mesangial cells, although the precise mechanisms remain unclear. We previously demonstrated that RhoA and its effector, Rho-kinase (Rho-associated coiled-coil containing protein kinase, ROCK), are involved in the… CONTINUE READING

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