Rho kinase inhibitor y27632 alters the balance between pluripotency and early differentiation events in human embryonic stem cells.

Abstract

Human embryonic stem cells (hESC) differentiate spontaneously in culture and develop a complex microenvironment comprising of autologously derived niche that in turn supports their pluripotency. The basic hypothesis that we deal with is that hESCs undergoing differentiation, sequentially generate trophectoderm and endoderm lineages and thereafter influence… (More)

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