Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension.

@article{Ocaranza2011RhoKI,
  title={Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension.},
  author={Mar{\'i}a Paz Ocaranza and Paulina Rodriguez Rivera and Ulises Novoa and Melissa Viana Vieira Pinto and L. G. Vega Gonzalez and Mario Chiong and Sergio Lavandero and Jorge E. Jalil},
  journal={Journal of hypertension},
  year={2011},
  volume={29 4},
  pages={
          706-15
        }
}
BACKGROUND Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho kinase activity. However, the relationship between Rho kinase activation and ACE2 in hypertension is unknown. OBJECTIVE The role of the Rho kinase signaling pathway in both enzymatic activity and aortic gene expression of ACE2 in deoxycorticosterone acetate (DOCA) hypertensive… CONTINUE READING
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