Rho kinase in the regulation of cell death and survival

  title={Rho kinase in the regulation of cell death and survival},
  author={Jianjian Shi and Lei Wei},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
Rho kinase (ROCK) belongs to a family of serine/threonine kinases that are activated via interaction with Rho GTPases. ROCK is involved in a wide range of fundamental cellular functions, such as contraction, adhesion, migration, and proliferation. Recent studies have shown that ROCK plays an important role in the regulation of apoptosis in various cell types and animal disease models. Two ROCK isoforms, ROCK1 and ROCK2, are assumed to be function redundant, this based largely on kinase… CONTINUE READING


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