Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

@article{Hamid2007RhoKA,
  title={Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.},
  author={Siti Norasyikin Abdul Hamid and Hugo S. Bower and Gary Francis Baxter},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 6},
  pages={
          H2598-606
        }
}
Intracellular signal transduction events in reperfusion following ischemia influence myocardial infarct development. Here we investigate the role of Rho kinase (ROCK) activation as a specific injury signal during reperfusion via attenuation of the reperfusion injury salvage kinase (RISK) pathway phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide (NO) synthase (eNOS). Rat isolated hearts underwent 35 min of left coronary artery occlusion and 120 min of reperfusion. Phosphorylation… CONTINUE READING
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