Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.

@article{Yagita2007RhokinaseAI,
  title={Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.},
  author={Yoshiki Yagita and Kazuo Kitagawa and Tsutomu Sasaki and Yasukazu Terasaki and Kenichi Todo and Emi Omura-Matsuoka and Kozo Kaibuchi and Masatsugu Hori},
  journal={Journal of neuroscience research},
  year={2007},
  volume={85 11},
  pages={2460-9}
}
Microcirculatory disturbances contribute to the expansion of infarct lesions after focal cerebral ischemia. Recently, it was shown that Rho-kinase involves in endothelial dysfunction via down-regulation of endothelial nitric oxide synthase function in a rodent stroke model. However, it is not clear whether endothelial Rho-kinase is activated in vivo or Rho-kinase activation contributes to microcirculatory disturbances after cerebral ischemia. In this study, we assessed the temporal and spatial… CONTINUE READING