Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling

  title={Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling},
  author={Hu Huang and Dong Geon Kong and Kyung Hee Byun and Chianping Ye and Shuichi Koda and Dae Ho Lee and Byung-chul Oh and Sam W. Lee and Bonghee Lee and Janice M. Zabolotny and Min Seon Kim and Christian Bj\orb{\ae}k and Bradford B. Lowell and Young-Bum Kim},
  booktitle={Nature Neuroscience},
Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical interaction of JAK2 and ROCK1, thereby increasing phosphorylation of JAK2 and downstream activation of Stat3 and FOXO1. Mice lacking ROCK1 in either pro-opiomelanocortin (POMC) or… CONTINUE READING
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