Rho-kinase Inhibitor Y-27632 Down-regulates LPS-induced IL-6 and IL-8 Production via Blocking p38 MAPK and NF-κB pathways in Human Gingival Fibroblasts.

Abstract

BACKGROUND Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) plays a major role in the initiation and progression of chronic periodontitis. Human gingival fibroblasts (HGFs) interact with bacteria or bacterial products and trigger inflammatory signaling pathways that destroy periodontal tissues. RhoA regulates cytokine production in various… (More)
DOI: 10.1002/JPER.17-0571

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