Rho-independent termination: dyad symmetry in DNA causes RNA polymerase to pause during transcription in vitro.

@article{Farnham1981RhoindependentTD,
  title={Rho-independent termination: dyad symmetry in DNA causes RNA polymerase to pause during transcription in vitro.},
  author={Peggy J. Farnham and T. Platt},
  journal={Nucleic acids research},
  year={1981},
  volume={9 3},
  pages={563-77}
}
Termination of transcription by RNA polymerase at rho-independent sites appears to depend primarily upon two structural features, a region of GC-rich dyad symmetry in the DNA preceding the stop point and a stretch of uridines at the 3' end of the transcript. The possibility that the former might be responsible for slowing elongation prompted us to perform a kinetic analysis of transcription across the leader and terminator regions of the E. coli tryptophan (trp) operon. Regions where the… CONTINUE READING

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