Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing.

@article{Baek2010RhofamilySG,
  title={Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing.},
  author={Seung Hee Baek and Young-Chang Kwon and Hyangkyu Lee and Kwang-Min Choe},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 3},
  pages={
          488-92
        }
}
A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis. Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound. The three GTPases are also required for actin cable formation at the wound leading edge. Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase (JNK) to organize actin… CONTINUE READING
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