Rho family GTPases.

@article{Hall2012RhoFG,
  title={Rho family GTPases.},
  author={Alan Hall},
  journal={Biochemical Society transactions},
  year={2012},
  volume={40 6},
  pages={
          1378-82
        }
}
  • A. Hall
  • Published 1 December 2012
  • Biology
  • Biochemical Society transactions
Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton, although, in addition, they promote a wide range of other cellular activities. Changes in the actin cytoskeleton drive many dynamic aspects of… 
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