Rho family GTPases regulate VEGF-stimulated endothelial cell motility.

  title={Rho family GTPases regulate VEGF-stimulated endothelial cell motility.},
  author={Norihito Soga and Noriko Namba and Shane McAllister and Larry Cornelius and Susan L. Teitelbaum and Steven F Dowdy and Juichi Kawamura and Keith A. Hruska},
  journal={Experimental cell research},
  volume={269 1},
Migration of endothelial cells induced by vascular endothelial growth factor (VEGF) is a critical step in angiogenesis. Stimulation of motility by growth factors such as VEGF requires interaction with the signal transduction pathways activated by the extracellular matrix (ECM). Here we demonstrate that the Rac GTPase is the critical intersection activated by type 1 collagen ECM and VEGF during stimulation of endothelial cell motility. To analyze the role of the Rho family GTPases in VEGF… CONTINUE READING


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