Rho-dependent membrane folding causes Shigella entry into epithelial cells.

  title={Rho-dependent membrane folding causes Shigella entry into epithelial cells.},
  author={Thomas Adam and Murielle Giry and Patrice Boquet and Philippe J Sansonetti},
  journal={The EMBO journal},
  volume={15 13},
The small GTPase rho is functionally involved in the formation of cytoskeletal structures like stress fibers or focal adhesion plaques. Shigella entry into HeLa cells induces a blossom-like membrane structure at the bacterial entry site. We show here that this membrane-folding process is rho-dependent. The three rho isoforms were recruited into bacterial entry sites with differential localization relative to the membrane structure. A rho-specific inhibitor abolished Shigella-induced membrane… CONTINUE READING
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