Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy.

Abstract

The Rho-associated (ROCK) serine/threonine kinases have emerged as central regulators of the actomyosin cytoskeleton, their main purpose being to promote contractile force generation. Aided by the discovery of effective inhibitors such as Y27632, their roles in cancer have been extensively explored with particular attention focused on motility, invasion and… (More)
DOI: 10.1038/embor.2012.127

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