Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.

@article{Walsh2011RhoassociatedKP,
  title={Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.},
  author={M. P. Walsh and Keith D. Thornbury and William C. Cole and Gerard P Sergeant and Mark A. Hollywood and Noel G. McHale},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={300 1},
  pages={F73-85}
}
The involvement of Rho-associated kinase (ROK) in activation of rabbit urethral smooth muscle contraction was investigated by examining the effects of two structurally distinct inhibitors of ROK, Y27632 and H1152, on the contractile response to electric field stimulation, membrane depolarization with KCl, and α1-adrenoceptor stimulation with phenylephrine. Both compounds inhibited contractions elicited by all three stimuli. The protein kinase C inhibitor GF109203X, on the other hand, had no… CONTINUE READING

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