Rho-associated kinase phosphorylates MARCKS in human neuronal cells.

  title={Rho-associated kinase phosphorylates MARCKS in human neuronal cells.},
  author={Hiromitsu Nagumo and Mami Ikenoya and Katsuhiko Sakurada and Kaoru Furuya and Toshihiko Ikuhara and Hisatoyo Hiraoka and Yasuharu Sasaki},
  journal={Biochemical and biophysical research communications},
  volume={280 3},
Myristoylated alanine-rich C kinase substrate (MARCKS) is a filamentous actin bundling protein and has multiple sites for phosphorylation, by which the biochemical function is negatively regulated. However, the role of such phosphorylation in physiological functions, particularly in neuronal functions, is not well understood. Using a phosphorylation-site specific antibody, we detected the phosphorylation of MARCKS at Ser159 by various protein kinases. Rho-kinase, protein kinase A, and protein… CONTINUE READING

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