Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability.


OBJECTIVES Vascular endothelial growth factor (VEGF) plays an important role in the regulation of microvascular permeability under various physiological and pathological conditions. The authors tested the hypothesis that the small GTPase Rho and its downstream effector ROCK (Rho-associated coiled-coil-containing protein kinase) mediate VEGF-induced… (More)


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