Rho-ROCK Signal Pathway Regulates Microtubule-Based Process Formation of Cultured Podocytes – Inhibition of ROCK Promoted Process Elongation

@article{Gao2004RhoROCKSP,
  title={Rho-ROCK Signal Pathway Regulates Microtubule-Based Process Formation of Cultured Podocytes – Inhibition of ROCK Promoted Process Elongation},
  author={Shuang-yan Gao and Chun-yu Li and Jie Chen and Lei Pan and Shouichiro Saito and Takehiro Terashita and Kyoko Saito and Kyojy Miyawaki and Kazuhiro Shigemoto and Katsumi Mominoki and Seiji Matsuda and Naoto Kobayashi},
  journal={Nephron Experimental Nephrology},
  year={2004},
  volume={97},
  pages={e49 - e61}
}
Background: Podocytes, renal glomerular visceral epithelial cells, have two kinds of processes, namely major processes containing microtubules (MTs) and foot processes with actin filaments (AFs). The present study investigated how MTs are organized by the Rho-ROCK signal transduction pathway during process formation of podocytes. Method: After induction of differentiation, podocytes of the conditionally immortalized mouse cell line were treated with Y-27632, a specific inhibitor of ROCK, and… 

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