Rho Proteins and Cancer

  title={Rho Proteins and Cancer},
  author={Anne J Ridley},
  journal={Breast Cancer Research and Treatment},
The Rho family of GTPases has been intensively studied for their roles in signal transduction processes leading to cytoskeletal-dependent responses, including cell migration and phagocytosis. In addition, they are important regulators of cell cycle progression and affect the expression of a number of genes, including those for matrix-degrading proteases implicated in cancer invasion. So far, the expression of some Rho family members has been found to be increased in some human cancers, and some… CONTINUE READING