Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.

@article{Xia2015RhoKI,
  title={Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.},
  author={Yun Xia and Xian-Yi Cai and Ji-Quan Fan and L Zhang and Jing-hua Ren and Jing Chen and Zhenyu Li and Rui-guang Zhang and Fang Zhu and Gang Wu},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 7},
  pages={
          1582-90
        }
}
The aim of this study was to investigate the biologic role of the Rho kinase inhibitor fasudil in the vasculogenic mimicry (VM) of B16 mouse melanoma cells. It was previously reported that RhoA plays a critical role in angiogenesis by coordinating endothelial cell cytoskeleton remodeling and promoting endothelial cell motility. Although RhoA has been implicated in the regulation of angiogenesis, little has been described regarding its control of these tumor cell-lined channels. In this study… CONTINUE READING
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