Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes.

@article{Delaguillaumie2002RhoGL,
  title={Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes.},
  author={Alix Delaguillaumie and C{\'e}cile Lagaudri{\`e}re-Gesbert and Michel R Popoff and H{\'e}l{\`e}ne Conjeaud},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 2},
  pages={
          433-43
        }
}
Activation of T lymphocytes requires the engagement of the T-cell receptor and costimulation molecules through cell-to-cell contacts. The tetraspanin CD82 has previously been shown to act as a cytoskeleton-dependent costimulation molecule. We show here that CD82 engagement leads to the tyrosine phosphorylation and association of both the Rho GTPases guanosine exchange factor Vav1 and adapter protein SLP76, suggesting that Rho GTPases participate in CD82 signaling. Indeed, broad inactivation of… CONTINUE READING

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