Rho GTPases as modulators of the estrogen receptor transcriptional response.

@article{Su2001RhoGA,
  title={Rho GTPases as modulators of the estrogen receptor transcriptional response.},
  author={Laura F Su and Roland E. Knoblauch and Michael J Garabedian},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 5},
  pages={3231-7}
}
The estrogen receptor alpha (ER) is a ligand-dependent transcription factor that plays a critical role in the development and progression of breast cancer, in part, by regulating target genes involved in cellular proliferation. To identify novel components that affect the ER transcriptional response, we performed a genetic screen in yeast and identified RDI1, a Rho guanine nucleotide dissociation inhibitor (Rho GDI), as a positive regulator of ER transactivation. Overexpression of the human… CONTINUE READING

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