Rho GTPases and signaling networks.

@article{Aelst1997RhoGA,
  title={Rho GTPases and signaling networks.},
  author={Linda Van Aelst and Crislyn D'Souza-Schorey},
  journal={Genes & development},
  year={1997},
  volume={11 18},
  pages={
          2295-322
        }
}
The Rho GTPases form a subgroup of the Ras superfamily of 20- to 30-kD GTP-binding proteins that have been shown to regulate a wide spectrum of cellular functions. These proteins are ubiquitously expressed across the species, from yeast to man. The mammalian Rho-like GTPases comprise at least 10 distinct proteins: RhoA, B, C, D, and E; Rac1 and 2; RacE; Cdc42Hs, and TC10. A comparison of the amino acid sequences of the Rho proteins from various species has revealed that they are conserved in… CONTINUE READING

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