Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells.

@article{CernudaMorolln2006RhoGA,
  title={Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells.},
  author={Eva Cernuda-Moroll{\'o}n and Anne J Ridley},
  journal={Circulation research},
  year={2006},
  volume={98 6},
  pages={757-67}
}
Rho family GTPases are key signal transducers that regulate cell adhesion and migration and a variety of other cellular responses, including changes in gene expression. In this review, we discuss how Rho GTPases regulate signaling by endothelial cell receptors involved in leukocyte extravasation. First, Rho GTPases affect the expression of some leukocyte adhesion molecules on endothelial cells, such as intracellular adhesion molecule-1 and E-selectin, that can be induced by proinflammatory… CONTINUE READING

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