Rho GTPases and cancer cell transendothelial migration.

Abstract

Small Rho GTPases are major regulators of actin cytoskeleton dynamics and influence cell shape and migration. The expression of several Rho GTPases is often up-regulated in tumors and this frequently correlates with a poor prognosis for patients. Migration of cancer cells through endothelial cells that line the blood vessels, called transendothelial… (More)
DOI: 10.1007/978-1-61779-442-1_9

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