Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.

@article{Ridley2006RhoGA,
  title={Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.},
  author={Anne J Ridley},
  journal={Trends in cell biology},
  year={2006},
  volume={16 10},
  pages={522-9}
}
Rho GTPases are well known to regulate actin dynamics. They activate two types of actin nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs), which induce different types of actin organization. Their ability to interact with membranes allows them to target actin polymerization to discrete sites on the plasma membrane and to intracellular membrane compartments and thereby induce membrane protrusions or regulate vesicle movement. Most studies have concentrated on just three of the… CONTINUE READING
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